Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Diego

Restaurants near Santa Fe Depot

Price
Cuisine
Top Rated
Dining Options
Seating options
Award-winning
Accessibility

40 restaurants available nearby

A photo of Seneca restaurant
1. Seneca
4.7
Exceptional(4120)
Price: Expensive
• Italian • Downtown
Booked 113 times today
Roman trattorias are a timeless expression of simplicity. Immune to the lure of gastronomic experimentation and ego. In Rome, no chef can cook better than the mothers and grandmothers before them. Our goal is to merge the dogmatic approach of Roman cooking with the amazing abundance of ingredients available to us in San Diego. A True Roman Holiday In SD. A 4% surcharge is added to all guest checks.
A photo of Animae restaurant
2. Animae
4.8
Exceptional(3183)
Price: Very Expensive
• Contemporary Asian • Downtown
Booked 74 times today
ANIMAE’s eclectic West Coast cuisine, layered with Asian influences, comes to life under Celebrated Chef Brian Malarkey. Applying a California cooking style to ANIMAE’S traditional coal-fired oven and grill, Chef Malarkey’s menu is as thoughtful as it is refined, elevating local produce and seasonal ingredients to create a lively and progressive culinary program.
A photo of Del Frisco’s Double Eagle Steakhouse - San Diego restaurant
3. Del Frisco’s Double Eagle Steakhouse - San Diego
4.5
Awesome(2327)
Price: Very Expensive
• Steakhouse • Downtown
Booked 26 times today
Del Frisco's Double Eagle Steakhouse embodies the rich tradition of the classic American steakhouse, serving USDA Prime Beef, fresh seafood and premium wines from our award-winning wine selection in a breathtaking atmosphere.
A photo of Ruth's Chris Steak House - San Diego restaurant
4. Ruth's Chris Steak House - San Diego
4.8
Exceptional(4960)
Price: Very Expensive
• Steakhouse • Downtown
Booked 72 times today
Now Open: We look forward to serving you soon.Ruth's Chris Steak House in San Diego, CA serves the finest USDA Prime beef available, broiled at 1,800° and served on 500° plates, so your steak stays hot, juicy and delicious from first bite to last. Enjoy our New Orleans-inspired appetizers, USDA Prime steaks, fresh seafood, signature side dishes and homemade desserts. All this while you enjoy our warm, inviting atmosphere and Ruth’s Chris’ genuine hospitality. So whether you’re a regular or have just been wondering what all the buzz is about, Ruth's Chris is the perfect excuse to enjoy the perfect night out. Dinner is served nightly, reservations are suggested and private dining and offsite catering may be arranged.
A photo of Vinarius restaurant
5. Vinarius
4.9
Exceptional(371)
Price: Moderate
• Italian • Downtown
Booked 9 times today
Vinarius is an Italian Restaurant & Wine Bar in Little Italy San Diego. We offer an extensive wine list with wines coming from different regions of the world; the best meat and cheese board with Italian cured meats and different cheeses to pair with our wines. Our chef Alex makes homemade pasta enriched with our homemade sauces, entrees, pizza, different appetizers to choose from, and desserts that pair well with our port wines and after-dinner drinks. You definitely have to try our daily specials! Our cozy full bar is also the perfect place to enjoy your drink and food while watching some sports!
A photo of King & Queen Cantina - San Diego restaurant
6. King & Queen Cantina - San Diego
4.5
Awesome(1173)
Price: Moderate
• Mexican • Little Italy
Booked 14 times today
*WALK-INS ALWAYS WELCOME*King and Queen Cantina brings Latin flavor to San Diego from creative founder and owner MR.TEMPO. Come for the atmosphere, but stay for the food. You will find all of your favorite Latin dishes infused with Asian flavors. Join us Happy Hour everyday, Weekend Brunch or Taco Tuesday for a dining experience like you’ve never experienced before! #MASCHINGON
A photo of Gaslamp Fish House restaurant
7. Gaslamp Fish House
4.0
Excellent(1229)
Price: Expensive
• Seafood • Downtown
Booked 3 times today
Gaslamp Fish House is opened. Our Guests and employee's safety is our main concern. We are taking extra action to keep everyone safe.We are offering a unique fusion of Mediterranean and American Cuisine. Our Oyster bar, Fresh Fish and Seafood, as well as all our Black Angus Grass Fed Beef are sourced locally from sustainable San Diego Fisheries and California Farms. Come to check us, seat and relax, our Team will do the rest. Our Address is : 411 Broadway - San Diego, CA 92101Across of the Grant Hotel - on the corner of 4th Street and Broadway
A photo of Petrini's restaurant
8. Petrini's
4.5
Awesome(424)
Price: Moderate
• Italian • Little Italy
Booked 2 times today
Petrini's, in the heart of San Diego's Little Italy neighborhood, serves homemade Italian dishes with a traditional authentic dishes. If you go to Music box, stop by for a dinner and a cup of wine before the show. We offer Brunch, Lunch and Dinner menus 7 days a week.The diablo shrimp in spicy wing sauce with lemon and cream, served with garlic cheese bread makes the perfect starter to your meal. Some of Petrini's' specialty entrée dishes include the smoked salmon alfredo sautéed with tomatoes and basil, garlic and rosemary served with spaghetti with tangy Pomodoro sauce and the baked white fish coated in seasoned bread crumbs in wine, butter and garlic sauce with Tuscan vegetables. Handhelds, such as the classic meatball hoagie, the vegetarian caponata sandwich with tomato-stewed eggplant and the craft-your-own pizzas, are other diner favorites.For a sweet end to your meal at Petrini's, enjoy a homemade classic Italian dessert, the layered tiramisu cake.
A photo of Topside Terrace restaurant
9. Topside Terrace
4.2
Awesome(385)
Price: Moderate
• Contemporary American • Downtown
Booked 3 times today
A quintessential San Diego open-air terrace, Topside Terrace takes advantage of the San Diego climate while marrying the sites and sounds of downtown. Inspired by coastal living, we specialize in evening fare and weekend brunch serving Baja California and Classic American Fare paired with contemporary cocktails and draft beer.Happy hour every Sunday-Thursday from 4pm to 6pm!Live Music every Wednesday night 6pm-8pm & Sunday Brunch 11am-1pm!
A photo of Above Ash restaurant
10. Above Ash
4.2
Awesome(149)
Price: Moderate
• Global, International • Little Italy
Booked 1 time today
Race You to the Rooftop! Above Ash Social is an intimate, welcoming rooftop bar on the 16th floor and rooftop of Carte Hotel. With glorious sunset views of San Diego cityscapes, relax near one of our fire pits and enjoy local focused beverages of every kind, from beer and wine to craft cocktails.Sign off a great day with a hand-crafted cocktail and delectable shared bites. Offering daily Happy Hour from 4pm to 6pm with discounted drinks and shareables. Age Policy: Above Ash welcomes guests 21+ only after 10pm. All ages are welcome at our lobby restaurant, Watercolors, located on the first floor.

Dining near Santa Fe Depot at a glance

Updated on

Most popular restaurant

popular restaurant

The Yasai: Vegan Japanese Experience at Little Italy

4.9

View restaurant

Discover local gems

Exceptional reviews
Search top-rated restaurants

Most popular cuisine

popular cuisine

Italian

Search Italian restaurants

Average bill amount

€25 and under
Search in this price range

See what locals rave about

From verified diners like you
From verified diners like you
  • Mike
    Palm Springs / Palm Desert Cities •2 reviews
    5.0
    Dined today
    The service was top notch and the food was great. The view was fabulous. We went for my 34 year anniversary and it was fantastic. I highly recommend it.
    More info
    SenecaPrice: Expensive• Italian• Downtown
    •
    4.7
  • Estrella
    San Diego •2 reviews
    5.0
    Dined 2 days ago
    They are amazing! My FAVORITE server Jacob is so attentive and makes sure that our drinks NEVER hits the bottom of the glass! I've NEVER had a bad plate. From the full entrees, appetizers, pizza and their salads it has ALL been so good. Great ingredients and so flavorful. They have the BEST espresso martitinis. Soooo good! Giuseppe the owner is always there ensuring that he helps his staff run the place so smoothly and checking in on all customers. Thank so much!!
    More info
    VinariusPrice: Moderate• Italian• Downtown
    •
    4.9
  • Emily
    Las Vegas •1 review
    5.0
    Dined 3 days ago
    Amazing food and staff. It was so cool to see elevated Filipino food, and it was my girlfriend’s first time trying A5 Wagyu, she said “it was the best thing I’ve ever put in my mouth”. Will be back in 6 months for my birthday!
    More info
    AnimaePrice: Very Expensive• Contemporary Asian• Downtown
    •
    4.8
  • Douglas
    San Diego •12 reviews
    5.0
    Dined on 25 Oct 2024
    We always have a good time and a good meal when visiting the Gaslamp Fish House. Waitress was friendly, knowledgeable, and fun. Thank you.
    More info
    Gaslamp Fish HousePrice: Expensive• Seafood• Downtown
    •
    4
  • Maryana
    San Diego •4 reviews
    5.0
    Dined on 12 Oct 2024
    Really nice during the day, drinks are really good
    More info
    Topside TerracePrice: Moderate• Contemporary American• Downtown
    •
    4.2

Explore OpenTable

Discover
OpenTable
  • About Us
  • Blog
  • Careers
More
Our sites
Businesses
  • Delight more diners
  • Restaurant Blog
Join us on
  • Privacy policy
  • Terms of Use
  • Impressum
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable International Ltd. Alphabeta Building, 14-18 Finsbury Square, London EC2A 1AH - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo