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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7
4.7
494 Reviews
$50 and over
Seafood

Make a booking

2 people
19:00
Booked 14 times today
Experiences are available.
  • Good for special occasions
  • Good for business meals
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: Turkey

    US$90.00 - US$135.00 per person

    22 Feb 2025 only
    Join us at M Brothers on Saturday, February 22, 2025, for the next stop on our Culinary Passport Dinners series! Savor a 4-course tasting menu inspired by the bold and vibrant flavors of Turkey. From the rich spices of Turkish cuisine to the fresh, savory ingredients that define it, this special menu will transport you to the heart of the Mediterranean. This experience is priced at $90 per person, or enhance your evening with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on February 22nd. Reserve your seat for this unforgettable culinary journey!
    Culinary Passport: Turkey photo
  • Culinary Passport: Peru

    US$90.00 - US$135.00 per person

    22 Mar 2025 only
    Join us at M Brothers on Saturday, March 22, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the vibrant and diverse flavors of Peru. From the zesty flavors to the heartwarming stews and unique Andean ingredients, this menu offers an elevated taste of Peruvian cuisine. This experience is priced at $90 per person, or enhance your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on March 22nd. Don’t miss this unforgettable culinary adventure!
    Culinary Passport: Peru photo

What 494 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.8Service
  • 4.7Ambience
  • 4.5Value

NoiseModerate

Diners' Choice Awards

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Food

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an "excellent experience" with beautifully presented, delicious dishes. Guests rave about the "outstanding service," with servers like Jordan and Destiny highly praised. The atmosphere is relaxing and perfect for conversations. Despite being located in a hospital, it's a "hidden gem" worth visiting for its exquisite food and attentive staff.

494 Reviews
  1. Andrew

    Atlanta

    1 review

    1.0

    1 review

    Dined 1 day ago

    1. Overall 1
    2. Food 4
    3. Service 1
    4. Ambience 3
    Had Valentine’s Day reservation, arrived and was seated. After about 15 minutes of waiting we asked for just waters to start. When the waitress returned with our waters she took our order (appetizers and entrees). We received our appetizers fairly quickly but then about 2 minutes later our entrees arrived. The food runner all jokes aside slid our obviously brand new appetizer plates out of the way to make room for our entrees. We then had to eat the appetizers as fast as possible to make sure our 50 dollar entrees weren’t ice cold by the time we ate them. Multiple people walked by including what seemed to be a manager who even stopped to ask how everything was (do you not see the full appetizer plates we have while our entrees sit off to the side getting cold?) we then ate our entrees with the empty appetizer plates on our table for the rest of the meal. Our waitress never returned after taking our order so we never got to order wine, or anything at all really. We legitimately were in and out of the place in 45 minutes. Food was good but for the price the service is laughably bad. Wouldn’t recommend at all.

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  2. Van

    Jacksonville

    7 reviews

    5.0

    7 reviews

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Nice place, recommend 10 out of 10 times. Service was excellent.

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  3. Michael

    Jacksonville

    8 reviews

    5.0

    8 reviews

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    We were not 100% sure what to expect with the restaurant being located in the atrium of the Mayo Hospital Cannaday Bldg. Beautifully designed Lounge and Dining room areas are what we discovered, Live music ( Sax Player) and a real candle on the table. Great service, outstanding apps, dinner and dessert. We would highly recommend M Brothers at Mayo to anyone who is in search of a great dining experience.

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  4. Rebekah

    VIP

    Jacksonville

    63 reviews

    5.0

    63 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    This remains our favorite restaurant in Jacksonville area. Service is always welcoming, accommodating and helpful. I have to add, they are so friendly and recognize us with each visit. The food is innovative, delicious and awesome! The cocktails are some of the best we've had. Wine selection has all our favorites. So glad to have this laid back, beautiful, hidden gem. I hate to give it the praise it deserves because I love it's easy to book and get in, but people need to know!

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  5. Klaas

    Jacksonville

    1 review

    5.0

    1 review

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The ambiance, food and service were excellent. We had a great time at MBrothers at Mayo clinic in Jacksonville!

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  6. Kevin

    Jacksonville

    7 reviews

    5.0

    7 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious food in a convenient and pleasant setting.

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  7. Catherine

    Charleston

    6 reviews

    5.0

    6 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    This was delicious! Highly recommend the bread service and the Steak Frites. Service was friendly and fast. What a nice treat and break this was during a long day of testing at the hospital.

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  8. Kristian

    VIP

    Caribbean

    17 reviews

    5.0

    17 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    A Fantastic Dining Experience! I had an amazing dinner at M Brothers at Mayo and everything was absolutely perfect! From the warm, welcoming ambiance to the impeccable service, every detail made the evening special. The food was outstanding—each dish was beautifully presented and bursting with flavor. The Short Rib with Pappardelle was a highlight, and the dessert was the perfect sweet ending. Highly recommend this place for a wonderful dining experience! Can’t wait to return. ⭐️⭐️⭐️⭐️⭐️

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  9. Frann

    VIP

    Kansas City

    3 reviews

    4.0

    3 reviews

    Dined 4 days ago

    1. Overall 4
    2. Food 4
    3. Service 4
    4. Ambience 5
    The ambiance was lovely and quiet. The shrimp etouffee was excellent. However the short rib carbonara was a disappointment. The carbonara sauce was bland, and the pappardelle was overcooked. Although the short rib was very tender, there was nothing exceptional about the dish. We would have expected more in terms of service, quality and value for such a high price point.

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  10. Katherine

    VIP

    Coastal Georgia

    2 reviews

    5.0

    2 reviews

    Dined on 8 February 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    One would never expect to have a fine dining experience in a hospital. Happily, M Brothers provides a dining experience that defies that expectation. The service is lovely, attentive but intrusive, and the food is wonderful. After a challenging few days supporting a loved one’s care, it was a welcome respite to relax in elegant surroundings with fine food. I recommend this restaurant when you are in Jacksonville even if you don’t need to be at Mayo for medical care.
    M Brothers at MayoResponded 6 days ago
    Thank you for your thoughtful review. We're so glad we could provide a comforting and enjoyable experience during a challenging time. Your kind words mean the world to us, and we will be sure to share your appreciation with your server. We look forward to welcoming you back!

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FAQs

M Brothers at Mayo is rated 4.7 stars by 494 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
19:00
Booked 14 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Privacy policy
  • Terms of Use
  • Impressum
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