Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. Jacksonville / Northeast Florida
  4. Jacksonville
  5. Jacksonville
M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
459 Reviews
$50 and over
Seafood

Make a booking

2 people
20:30
Booked 7 times today
  • Good for business meals
  • Good for special occasions
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

What 459 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.7Ambience
  • 4.4Value

NoiseModerate

Diners' Choice Awards

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Innovative

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience with "innovative, fresh" dishes and "excellent" service. The restaurant's ambiance, located in the Mayo Clinic, is both "lovely" and "relaxing." Diners rave about the "fantastic" meals, including monthly special dinners and wine pairings. It's a "hidden gem" worth discovering.

459 Reviews
  1. Mary

    VIP

    New York City

    47 reviews

    5.0

    47 reviews

    Dined 3 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fabulous dinner. Service was excellent We did the Japan dinner with wine pairings. Looking forward to the next one.
    M Brothers at MayoResponded 1 day ago
    Thank you for joining us for the Japan dinner! We’re thrilled you enjoyed the fabulous meal and wine pairings. Can’t wait to see you at the next one! 🍷🍣

    Is this helpful?

  2. Julie

    VIP

    Jacksonville

    14 reviews

    5.0

    14 reviews

    Dined 6 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Can I tell you how happy I am to get a Medure/Matthew's quality meal without having to suffer through the PV or downtown traffic? Douglas, our server, was so friendly and personable. It took a moment to adjust to eating a fine meal in a hospital, but it really was fantastic. We had the calamari, French onion soup, tonight's sea bass special, and the filet. All fantastic!!! Highly recommend!
    M Brothers at MayoResponded 1 day ago
    Thank you for the wonderful review! We're thrilled you enjoyed a Medure/Matthew's quality meal without the traffic. Douglas will be so pleased to hear your kind words! It’s great to know the atmosphere grew on you and that each dish exceeded expectations. We truly appreciate the recommendation and hope to see you again soon! 🍴✨

    1 person found this helpful

  3. Laurie

    Jacksonville

    1 review

    5.0

    1 review

    Dined on 9 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Many people stopped by to say hello. They knew us and were friendly. Our server, Jordan, went above and beyond to care for us.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your kind words! We're thrilled to hear that Jordan and our team made you feel so welcome. We look forward to hosting you again soon! 😊🍴

    Is this helpful?

  4. GEORGE

    Charleston

    10 reviews

    2.0

    10 reviews

    Dined on 3 December 2024

    1. Overall 2
    2. Food 2
    3. Service 4
    4. Ambience 2
    I Had lunch numerous time there and was very happy first time dinner there the food was over cooked and dry mostly fried calamari French onion soup and triple tail fish of the day Very cafeteria style taste and donneness Very disappointed
    M Brothers at MayoResponded on 12 December 2024
    We're sorry to hear about your dinner experience and appreciate your feedback. This isn’t the standard we strive for, and we’ll address it with our team. We hope you’ll give us another chance to impress you.

    Is this helpful?

  5. Ellwood

    VIP

    New York City

    14 reviews

    5.0

    14 reviews

    Dined on 23 November 2024

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    The monthly food/wine tastings are exceptional. We never miss them. Morocco cuisine is just not my favorite. While the preparation and quality is excellent, I have never been a big fan of the spices particular to the area. The saxophonist played well, but it was a little loud.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your loyalty to our tastings! We’re glad you enjoyed the quality and preparation. We’ll pass along your feedback about the volume and look forward to welcoming you back for another exceptional evening! 🍷✨

    Is this helpful?

  6. Helen

    London

    37 reviews

    5.0

    37 reviews

    Dined on 21 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Dining at M Brothers is consistently great! Food is always delicious and perfectly prepared. The menu is filled with things we enjoy eating. And it is all served and delivered by your delightful team. Destiny is a worthy and engaging ambassador. I always look forward to seeing her. Makes the experience that much more special. M Brothers is a true gem.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your heartfelt review and kind words about Destiny! We're thrilled to hear she has such a positive impact on your visits and makes your experience extra special. We'll be sure to share your feedback with her and the team. It means the world to us to be a comforting part of your journey. 💙🍴

    Is this helpful?

  7. Margaret

    VIP

    Calgary

    3 reviews

    5.0

    3 reviews

    Dined on 20 November 2024

    1. Overall 5
    2. Food 5
    3. Service 3
    4. Ambience 4
    Wonderful food!! So convenient to have an outstanding and high quality restaurant at Mayo.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your kind words! We're delighted to provide a convenient and high-quality dining experience at M Brothers at Mayo. We look forward to serving you again soon! 😊🍴

    Is this helpful?

  8. Cristina

    Jacksonville

    1 review

    4.0

    1 review

    Dined on 19 November 2024

    1. Overall 4
    2. Food 5
    3. Service 4
    4. Ambience 3
    Risotto special was amazing !!!! Service was great. Amazing homemade bread
    M Brothers at MayoResponded on 12 December 2024
    Thank you for the glowing review! We're thrilled you loved the risotto special and our homemade bread. Looking forward to welcoming you back soon! 🍞✨🍽️

    Is this helpful?

  9. Melissa

    Atlanta Metro

    28 reviews

    5.0

    28 reviews

    Dined on 11 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Jordan was a delight as a server and guide to all your wonderful dishes. I will miss the roasted beet salad as you are changing menus but look forward to your new menu in January when I return.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your lovely review! We're thrilled to hear Jordan made your visit so special. While we'll miss the roasted beet salad too, we can't wait to share our new menu with you in January. Safe travels, and see you soon! 😊🍽️

    Is this helpful?

  10. Jeannie

    Denver

    2 reviews

    5.0

    2 reviews

    Dined on 9 November 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fabulous food. Lovely pottery dishes. Great wait staff! Great bread
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your kind words! We're so glad you enjoyed the food, pottery, and our amazing team. We can't wait to serve you again!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.8 stars by 459 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
20:30
Booked 7 times today
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Privacy policy
  • Terms of Use
  • Impressum
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable International Ltd. Alphabeta Building, 14-18 Finsbury Square, London EC2A 1AH - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo