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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
466 Reviews
$50 and over
Seafood

Make a booking

2 people
19:00
Booked 10 times today
Experiences are available.
  • Good for special occasions
  • Good for business meals
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: The United Kingdom

    US$90.00 - US$135.00 per person

    18 Jan 2025 only
    Join us at M Brothers on Saturday, January 18, 2025, for the first stop on our Culinary Passport Dinners series! (Formerly "If It Grows Together, It Goes Together") Embark on a 4-course tasting journey inspired by the rich and diverse flavors of The United Kingdom. From hearty classics to refined British fare, this unique menu will take you through the best of British cuisine. This experience is priced at $90 per person, or elevate your experience with curated wine or alcohol pairings for each course for $135. This special menu will ONLY be available on January 18th. Don’t miss out on this unforgettable culinary adventure!
  • Culinary Passport: Turkey

    US$90.00 - US$135.00 per person

    22 Feb 2025 only
    Join us at M Brothers on Saturday, February 22, 2025, for the next stop on our Culinary Passport Dinners series! Savor a 4-course tasting menu inspired by the bold and vibrant flavors of Turkey. From the rich spices of Turkish cuisine to the fresh, savory ingredients that define it, this special menu will transport you to the heart of the Mediterranean. This experience is priced at $90 per person, or enhance your evening with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on February 22nd. Reserve your seat for this unforgettable culinary journey!
  • Culinary Passport: Peru

    US$90.00 - US$135.00 per person

    22 Mar 2025 only
    Join us at M Brothers on Saturday, March 22, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the vibrant and diverse flavors of Peru. From the zesty flavors to the heartwarming stews and unique Andean ingredients, this menu offers an elevated taste of Peruvian cuisine. This experience is priced at $90 per person, or enhance your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on March 22nd. Don’t miss this unforgettable culinary adventure!

What 466 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.6Ambience
  • 4.4Value

NoiseModerate

Diners' Choice Awards

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Innovative

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience with "innovative, fresh" dishes and "excellent" service. The restaurant's ambiance, located in the Mayo Clinic, is both "lovely" and "relaxing." Diners rave about the "fantastic" meals, including monthly special dinners and wine pairings. It's a "hidden gem" worth discovering.

466 Reviews
  1. Robert

    Charlotte

    35 reviews

    5.0

    35 reviews

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Our first time at M Brothers at Mayo Clinic, super convenient access from the parking deck, with free valet parking. The food was outstanding as was the service provided by Kaley and all other members of the staff as well. Definitely recommend giving it a try, I think you will be pleased with the experience.
    M Brothers at MayoResponded today
    Thank you for dining with us at M Brothers at Mayo Clinic! We're delighted you enjoyed the convenient access, outstanding food, and exceptional service from Kaylee and our team. We'll be sure to share your kind words with her. We hope to welcome you back again soon!

    Is this helpful?

  2. Brenda

    VIP

    Jacksonville

    78 reviews

    5.0

    78 reviews

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The evening could not have been better. Our hat is off to the staff and the food. It is so nice to dine somewhere you can actually have a conversation with having to raise your voice and keep asking people to repeat what they said. HIghly recommend this “hidden” jewel.
    M Brothers at MayoResponded today
    Thank you for your glowing review! We're thrilled you enjoyed the peaceful ambiance, exceptional food, and attentive staff. Your kind words mean the world to us—hope to see you again soon!!

    Is this helpful?

  3. Tracy

    New Jersey

    4 reviews

    5.0

    4 reviews

    Dined 1 day ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent dinner-food, atmosphere, and service! Our waitress, Kaely was attentive and helpful! This is def a hidden gem!

    Is this helpful?

  4. Harrell

    Jacksonville

    4 reviews

    3.0

    4 reviews

    Dined 2 days ago

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    Sea bass needed a vegetable side. I would describe Potato wedges with ribeye as a failed test. Dry seasoning on them was bad.

    Is this helpful?

  5. Bunnie

    VIP

    Jacksonville

    5 reviews

    5.0

    5 reviews

    Dined 3 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Celebrating a friends Birthday was a perfect evening. Staff very attentive, professional and friendly. Food and wine was a 10 ++
    M Brothers at MayoResponded 2 days ago
    Thank you for celebrating with us! We’re thrilled to hear you had a perfect evening with attentive service and incredible food and wine. Hope to see you again soon! 🥂✨

    Is this helpful?

  6. Chris

    VIP

    Jacksonville

    54 reviews

    5.0

    54 reviews

    Dined on 24 December 2024

    1. Overall 5
    2. Food 5
    3. Service 3
    4. Ambience 5
    everything was great last night--food was excellent and drinks were wonderful only problem was the server was sniffling and coughing and sneezing from the first time she came to wait on us so that was an issue that needs corrected
    M Brothers at MayoResponded 7 days ago
    Thank you for your feedback and for dining with us. We're glad you enjoyed the food and drinks! We sincerely apologize for the issue with the server and will address it to ensure a better experience in the future.

    Is this helpful?

  7. Anne

    VIP

    Chicago

    8 reviews

    5.0

    8 reviews

    Dined on 24 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    It was a treat to have a nice lunch (with wine!) during a day of medical appointments. Food was delicious and Douglas was a terrific server. We’ll be back!
    M Brothers at MayoResponded 7 days ago
    Thank you for joining us for lunch! We're delighted you enjoyed the food (and wine!) and appreciated Douglas's terrific service. We look forward to seeing you again soon!

    Is this helpful?

  8. Mary

    VIP

    New York City

    47 reviews

    5.0

    47 reviews

    Dined on 21 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fabulous dinner. Service was excellent We did the Japan dinner with wine pairings. Looking forward to the next one.
    M Brothers at MayoResponded on 23 December 2024
    Thank you for joining us for the Japan dinner! We’re thrilled you enjoyed the fabulous meal and wine pairings. Can’t wait to see you at the next one! 🍷🍣

    Is this helpful?

  9. Julie

    VIP

    Jacksonville

    14 reviews

    5.0

    14 reviews

    Dined on 18 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Can I tell you how happy I am to get a Medure/Matthew's quality meal without having to suffer through the PV or downtown traffic? Douglas, our server, was so friendly and personable. It took a moment to adjust to eating a fine meal in a hospital, but it really was fantastic. We had the calamari, French onion soup, tonight's sea bass special, and the filet. All fantastic!!! Highly recommend!
    M Brothers at MayoResponded on 23 December 2024
    Thank you for the wonderful review! We're thrilled you enjoyed a Medure/Matthew's quality meal without the traffic. Douglas will be so pleased to hear your kind words! It’s great to know the atmosphere grew on you and that each dish exceeded expectations. We truly appreciate the recommendation and hope to see you again soon! 🍴✨

    1 person found this helpful

  10. Laurie

    Jacksonville

    1 review

    5.0

    1 review

    Dined on 9 December 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Many people stopped by to say hello. They knew us and were friendly. Our server, Jordan, went above and beyond to care for us.
    M Brothers at MayoResponded on 12 December 2024
    Thank you for your kind words! We're thrilled to hear that Jordan and our team made you feel so welcome. We look forward to hosting you again soon! 😊🍴

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.8 stars by 466 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a booking

2 people
19:00
Booked 10 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Area
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Privacy policy
  • Terms of Use
  • Impressum
  • Cookies and Interest-Based Ads
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